Dr. Frederick W. K. Tam

I have been investigating the importance of cytokines in pathogenesis of glomerulonephritis, diabetic nephropathy and renal allograft rejection. My research group has developed experimental therapies of glomerulonephritis using soluble cytokine receptor, receptor antagonist and monoclonal antibodies, recombinant regulatory cytokines and signal transduction inhibitors. I have also applied the experience from cytokine analysis and proteomics to development of non-invasive biomarkers for kidney diseases. Together with the Transplantation Translational Research Group, I am investigating the novel mechanisms of renal transplant rejection and developing novel anti-rejection therapy (supported by Kidney Research UK Making Every Kidney Count Programme Grant). I am also the Founding Lead of the UK Rare Disease Group for Retroperitoneal Fibrosis. I have been collaborating with the industry in the preclinical and early clinical development of anti-inflammatory therapies.

Board certifications